纳米颗粒疫苗自1981 年首次应用于人体以来, 经历逾40 年的发展历程, 在临床应用方面已取得
了极大成功. 尤其是在乙型肝炎病毒(hepatitis B virus, HBV), 人乳头瘤病毒(human …

Nanoparticle vaccines have firmly established themselves as a cornerstone of modern
immunization strategies, with a compelling history that traces its origins back to their …

摘要目前, 研究开发出安全性好且能有效刺激机体细胞免疫和体液免疫的疫苗及其载体和佐剂是
绝大多数传染病疫苗研发中的瓶颈问题. 鉴于病毒载体疫苗潜在的安全性问题, 近年来DNA …

Prophylactic vaccines that can generate long-lasting protective immune responses are
needed for many infectious diseases. Efficient vaccination requires vaccine antigens to be …

Vaccines represent one of the most successful public health initiatives worldwide. However,
despite the vast number of highly effective vaccines, some infectious diseases still do not …

Despite the discovery of many potential antigens for subunit vaccines, universal protection is
often lacking due to the limitations of conventional delivery methods. Subunit vaccines …

Nanoparticle vaccines are a diverse category of vaccines for the prophylaxis or treatment of
various diseases. Several strategies have been employed for their optimization, especially …

Increasing emergence of infectious diseases is driving demand for new vaccine
technologies capable of improving antigen delivery and protective efficacy. Nanoparticle …

Highlights•Current vaccine designs fall short for emerging diseases and the developing
world.•Single dose polymeric nanoparticles can provide initial and boosting …