Targeting autophagy with natural products as a potential therapeutic approach for cancer

MAA Al-Bari, Y Ito, S Ahmed, N Radwan… - International journal of …, 2021 - mdpi.com
Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-
digestion caused by lysosomes on demand, which is upregulated as a survival strategy …

Research progress on the anticancer molecular mechanism of targets regulating cell autophagy

T Zhang, J Yu, S Cheng, Y Zhang, C Zhou, J Qin… - Pharmacology, 2023 - karger.com
Background: Autophagy is a lysosome-mediated catabolic process that maintains cell
homeostasis and survival. It occurs not only in normal cells such as cardiac muscle cells …

New visions on natural products and cancer therapy: autophagy and related regulatory pathways

A Martelli, M Omrani, M Zarghooni, V Citi, S Brogi… - Cancers, 2022 - mdpi.com
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Molecular insights into the multifunctional role of natural compounds: autophagy modulation and cancer prevention

MA Rahman, MDH Rahman, MS Hossain, P Biswas… - Biomedicines, 2020 - mdpi.com
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein
molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress …

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

[HTML][HTML] Unfolding the role of autophagy in the cancer metabolism

A Pandey, P Yadav, S Shukla - Biochemistry and Biophysics Reports, 2021 - Elsevier
Autophagy is considered an indispensable process that scavenges toxins, recycles complex
macromolecules, and sustains the essential cellular functions. In addition to its …

Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Seeking new anti-cancer agents from autophagy-regulating natural products

F Hua, S Shang, ZW Hu - Journal of Asian natural products …, 2017 - Taylor & Francis
Natural products are an important original source of many widely used drugs, including anti-
cancer drugs. Early research efforts for seeking anti-cancer therapy from the natural …

Autophagy and its potent modulators from phytochemicals in cancer treatment

CY Sun, QY Zhang, GJ Zheng, B Feng - Cancer chemotherapy and …, 2019 - Springer
Autophagy is a ubiquitous catabolic process by which damaged or harmful intracellular
components are delivered to the lysosomes for self-digestion and recycling. It is critical in …