An accumulating body of evidence has indicated that inflammation in the absence of
pathogens, which is referred to as sterile inflammation, is mediated through an …

With much interest we have read the recently published article by Sandanger et al., 1 where
NLRP3 mRNA expression was shown to be increased3–7daysfollowingpermanentocclusion …

With much interest we have read the recently published article by Sandanger et al.(2013) 1
where NLRP3 mRNA expression was shown to be increased 3-7 days following permanent …

Aims N ucleotide-binding oligomerization domain-L ike R eceptor with a P yrin domain 3
(NLRP3) is considered necessary for initiating a profound sterile inflammatory response …

The Nlrp3 inflammasome is a protein complex consisting of NLRP3, ASC and caspase-1,
that upon activation produces a potent proinflammatory cytokine, IL-1β. Evidence has …

Inflammasomes are multiple protein complexes that serve as molecular platforms to activate
caspase-1 and regulate maturation of a potent proinflammatory cytokine, interleukin (IL)-1β …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

An accumulating body of evidence indicates that inflammation plays a crucial role in the
pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain …

Aims The NLRP3 inflammasome is activated in the ischaemic heart promoting caspase-1
activation, inflammation, and cell death. Ischaemic injury establishes both a priming signal …

Background The innate immune receptor NLRP3 recognizes tissue damage and initiates
inflammatory processes through formation multiprotein complexes with the adaptor protein …