Therapeutic potential of umbilical cord blood cells for type 1 diabetes mellitus: 脐血来源细胞治疗1 型糖尿病的潜能

B He, X Li, H Yu, Z Zhou - Journal of diabetes, 2015 - Wiley Online Library
摘要1 型糖尿病是一类由自身免疫反应介导, 致使胰岛β 细胞损伤的慢性疾病.
传统的治疗方法并不能治愈该疾病. 针对1 型糖尿病发病机制, 抑制自身免疫, 恢复免疫平衡 …

Human cord blood stem cells and the journey to a cure for type 1 diabetes

Y Zhao, T Mazzone - Autoimmunity reviews, 2010 - Elsevier
Umbilical cord blood contains several types of stem cells that are of interest to a wide range
of disciplines in regenerative medicine. The translational potential to the clinical applications …

New type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes

Y Zhao, B Lin, M Dingeldein, C Guo, D Hwang… - Translational …, 2010 - Elsevier
Type 1 diabetes (T1D) is an autoimmune disease caused by an autoimmune destruction of
pancreatic islet insulin-producing cells. Autoimmunity and shortage of insulin-producing …

New hope for type 2 diabetics: Targeting insulin resistance through the immune modulation of stem cells

Y Zhao, Z Jiang, C Guo - Autoimmunity reviews, 2011 - Elsevier
The prevalence of type 2 diabetes (T2D) is increasing worldwide, highlighting the need for a
better understanding of the pathogenesis of the disease and the development of innovative …

Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes

R Stiner, M Alexander, G Liu, W Liao, Y Liu, J Yu… - Cell and tissue …, 2019 - Springer
In recent years, human umbilical cord blood has emerged as a rich source of stem, stromal
and immune cells for cell-based therapy. Among the stem cells from umbilical cord blood …

[HTML][HTML] Autologous umbilical cord blood infusion for type 1 diabetes

MJ Haller, HL Viener, C Wasserfall, T Brusko… - Experimental …, 2008 - Elsevier
OBJECTIVE: The physical, emotional, and economic costs of type 1 diabetes (T1D) mandate
continued efforts to develop effective strategies to prevent or reverse the disease. Herein, we …

Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus.

D Kong, X Zhuang, D Wang, H Qu, Y Jiang, X Li… - Clinical …, 2014 - europepmc.org
Background Type 2 diabetes mellitus (T2DM) is a serious threat to human health and
remains incurable. Insulin deficiency seems to be attributed to the progressive failure of …

[HTML][HTML] Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

Y Zhao, Z Jiang, T Zhao, M Ye, C Hu, Z Yin, H Li… - BMC medicine, 2012 - Springer
Background Inability to control autoimmunity is the primary barrier to developing a cure for
type 1 diabetes (T1D). Evidence that human cord blood-derived multipotent stem cells (CB …

[HTML][HTML] 人脐带间充质干细胞联合免疫干预治疗1 型糖尿病小鼠的实验研究

郭波, 刘佳, 崔晓兰, 时瀚, 张社毅, 王嘉, 山霞… - 中国组织工程研究, 2019 - cjter.com
摘要背景: 1 型糖尿病是一种以T 细胞介导的胰岛β 细胞损伤为特征的自身免疫性疾病,
实验拟针对其免疫机制进行干预, 并用干细胞修复受损的胰岛β 细胞, 探索治疗1 …

[HTML][HTML] The potential utility of bone marrow or umbilical cord blood transplantation for the treatment of type I diabetes mellitus

M Mabed - Biology of Blood and Marrow Transplantation, 2011 - Elsevier
The pathology of type 1 diabetes mellitus (T1D) involves the autoimmune destruction or
malfunction of pancreatic β cells, leading to a lack of insulin. The absence of insulin is life …