Danshensu alleviates bleomycin-induced pulmonary fibrosis by inhibiting lung fibroblast-to-myofibroblast transition via the MEK/ERK signaling pathway
H Liu, X Zhang, Y Shao, X Lin, F Dong, X Liu - Bioengineered, 2021 - Taylor & Francis
Pulmonary fibrosis (PF) is a chronic pulmonary interstitial disease, and its pathological
process is closely related to fibroblast–myofibroblast differentiation. Danshensu (DSS) has …
process is closely related to fibroblast–myofibroblast differentiation. Danshensu (DSS) has …
Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through the wingless/integrase-1 signaling pathway
Y Wang, X Dong, N Zhao, X Su, Y Wang… - Experimental lung …, 2020 - Taylor & Francis
Abstract Purpose/Aim: Pulmonary fibrosis (PF) is characterized by the progressive and
ultimately fatal accumulation of fibroblasts and extracellular matrix in the lung that distorts its …
ultimately fatal accumulation of fibroblasts and extracellular matrix in the lung that distorts its …
[HTML][HTML] Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
P Liu, K Miao, L Zhang, Y Mou, Y Xu, W Xiong, J Yu… - Respiratory …, 2020 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease
characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic …
characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic …
Bergenin attenuates bleomycin‐induced pulmonary fibrosis in mice via inhibiting TGF‐β1 signaling pathway
X Li, Y Wang, J Liang, Z Bi, H Ruan, Y Cui… - Phytotherapy …, 2021 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by epithelial
cell damage, fibroblast activation, and collagen deposition. IPF has high mortality and …
cell damage, fibroblast activation, and collagen deposition. IPF has high mortality and …
[HTML][HTML] Mefunidone ameliorates bleomycin-induced pulmonary fibrosis in mice
Y Han, M Jiang, R He, X Lv, X Liao, Y He… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial
lung diseases with poor prognosis. Currently, few effective drugs are available for IPF …
lung diseases with poor prognosis. Currently, few effective drugs are available for IPF …
[HTML][HTML] Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation
R Guan, X Wang, X Zhao, N Song, J Zhu, J Wang… - Scientific reports, 2016 - nature.com
Aberrant activation of TGF-β1 is frequently encountered and promotes epithelial-
mesenchymal transition (EMT) and fibroblast activation in pulmonary fibrosis. The present …
mesenchymal transition (EMT) and fibroblast activation in pulmonary fibrosis. The present …
[HTML][HTML] Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway
J Li, Q Wei, K Song, Y Wang, Y Yang, M Li… - Frontiers in …, 2023 - frontiersin.org
Background: Pulmonary fibrosis (PF) is a terminal pathological change in a variety of lung
diseases characterized by excessive deposition of extracellular matrix, for which effective …
diseases characterized by excessive deposition of extracellular matrix, for which effective …
[HTML][HTML] Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation
Q Wang, J Yu, Y Hu, X Chen, L Zhang, T Pan… - Biomedicine & …, 2020 - Elsevier
Background and objective Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial
lung disease with a poor prognosis. Indirubin, a compound obtained from indigo-bearing …
lung disease with a poor prognosis. Indirubin, a compound obtained from indigo-bearing …
[HTML][HTML] Nintedanib inhibits endothelial mesenchymal transition in bleomycin-induced pulmonary fibrosis via focal adhesion kinase activity reduction
WK Yu, WC Chen, VYF Su, HC Shen, HH Wu… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD). Pulmonary
fibroblasts play an important role in the development of IPF. Emerging evidence indicates …
fibroblasts play an important role in the development of IPF. Emerging evidence indicates …
[HTML][HTML] Vincamine Ameliorates epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis in rats; targeting TGF-β/MAPK/Snai1 pathway
Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to
respiratory failure and death. Vincamine is an indole alkaloid obtained from the leaves of …
respiratory failure and death. Vincamine is an indole alkaloid obtained from the leaves of …