Matrix metalloproteinases and bone

SM Krane, M Inada - Bone, 2008 - Elsevier
… sections utilizing the Bodian stain [83], it was evident that the canalicular network through
which osteocytes communicate with each other and with bone forming cells at bone surfaces

Bone tissue remodeling and development: focus on matrix metalloproteinase functions

KBS Paiva, JM Granjeiro - Archives of biochemistry and biophysics, 2014 - Elsevier
… This organization allows osteocytes to communicate with each other and osteoblasts/osteoclasts
at bone surfaces, in both the periosteum and endosteum, by gap junction-coupled cell …

Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis

JA Nemeth, R Yousif, M Herzog, M Che… - Journal of the …, 2002 - academic.oup.com
… One of the steps involved in the cycle of bone turnover is the migration of osteoclasts to
bone surfaces; MMP activity has been shown to be required for osteoclast migration in …

Immunolocalization of matrix metalloproteinase-13 on bone surface under osteoclasts in rat tibia

H Nakamura, G Sato, A Hirata, T Yamamoto - Bone, 2004 - Elsevier
… In trabecular bone of the epiphysis, MMP-13-positive lines were detected … bone surface
and in bone matrix. We refer to laminar structures between new bone matrix and old bone matrix

Matrix metalloproteinases in bone resorption, remodeling, and repair

KBS Paiva, JM Granjeiro - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) and …

Extracellular matrix remodelling: the role of matrix metalloproteinases

I Stamenkovic - The Journal of Pathology: A Journal of the …, 2003 - Wiley Online Library
… Osteoclasts are recruited to bone surfaces during bone remodelling, and their migration
through collagen gels is blocked by MMP inhibitors 85. In a model of neuronal differentiation, the …

Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption

P Hou, T Troen, MC Ovejero, T Kirkegaard… - Bone, 2004 - Elsevier
… These activities involve recognition, migration, spreading and attachment of the osteoclasts
to the bone surface [2], which implies interactions with bone matrix proteins, such as type I …

Proteinases involved in matrix turnover during cartilage and bone breakdown

TE Cawston, DA Young - Cell and tissue research, 2010 - Springer
… cell surface (MT-MMP membrane-type matrix metalloproteinase). MMPs can be activated at
the cell surface … Some cell surface proteins can bind MMPs localising them to cleave proteins …

The effect of matrix metalloproteinase inhibition on tendon-to-bone healing in a rotator cuff repair model

A Bedi, D Kovacevic, C Hettrich, LV Gulotta… - Journal of shoulder and …, 2010 - Elsevier
… on tendon-to-bone surface healing after acute rotator cuff repair. We used an established
rat rotator cuff repair model to evaluate tendon-to-bone surface healing with immediate …

Matrix metalloproteinases

LL Johnson, R Dyer, DJ Hupe - Current opinion in chemical biology, 1998 - Elsevier
… and, in situations where collagen is present on the bone surface, can use this … of bone
resorption, … Although this article does not specifically describe matrix metalloproteinase (MMP) …