Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

S Higashi, S Biskup, AB West, D Trinkaus, VL Dawson… - Brain research, 2007 - Elsevier
… Immunohistochemical localization of LRRK2 in the SNpc of Parkinson's disease (PD)
brain. (a, b) Detailed localization of LRRK2 in the SNpc of normal control (a) and PD (b) …

Studies on genomic DNA topology and stability in brain regions of Parkinson's disease

ML Hegde, VB Gupta, M Anitha, T Harikrishna… - Archives of biochemistry …, 2006 - Elsevier
Parkinson’s disease (PD). In the present study, genomic DNA was isolated from eight brain
regions … confirmed cases of Parkinson’s disease and six control brains and analyzed for the …

Circuit mechanisms of Parkinson's disease

MM McGregor, AB Nelson - Neuron, 2019 - cell.com
… However, more detailed study of disease symptoms and postmortem brain pathology suggest
… Lewy bodies are found in different regions of the postmortem brain, often, but not always, …

Basal ganglia circuits changes in Parkinson's disease patients

T Wu, J Wang, C Wang, M Hallett, Y Zang, X Wu… - Neuroscience …, 2012 - Elsevier
… The present study, for the first time, identified brain regions whose activity follows or predicts
activations in the SNc, and how these “causal” connections were abnormal in PD. The novel …

Neuroimaging of Parkinson's disease: Expanding views

CP Weingarten, MH Sundman, P Hickey… - … & Biobehavioral Reviews, 2015 - Elsevier
… The most well known neurobiological model of PD has provided a simplified schema for
how changes in neurotransmitters and brain regions and networks can be the basis of motor …

Abnormal regional brain function in Parkinson's disease: truth or fiction?

Y Ma, C Tang, JR Moeller, D Eidelberg - Neuroimage, 2009 - Elsevier
Parkinson’s disease (PD) and use computer simulations to show that lower global values can
produce spurious increases in subcortical brain regions. … changes in brain function. In this …

Glutathionerelated enzymes in brain in Parkinson's disease

J Sian, DT Dexter, AJ Lees, S Daniel… - Annals of Neurology …, 1994 - Wiley Online Library
Brain tissue was obtained from patients dying with a clinical diagnosis of PD or MSA and …
the Parkinson's Disease Society Brain Bank, Queen Square, London. At autopsy brains were …

Etiology and pathogenesis of Parkinson's disease

AH Schapira, P Jenner - Movement disorders, 2011 - Wiley Online Library
… this is identical in all brain regions where pathology occurs and in all individuals with
Parkinson's disease. Focusing on those events that characterize Parkinson's disease, namely, …

Personality traits and brain dopaminergic function in Parkinson's disease

V Kaasinen, E Nurmi, J Bergman… - Proceedings of the …, 2001 - National Acad Sciences
… with the parkinsonian personality, was slightly lower in the Parkinson's disease group …
relationship with 18 F-dopa uptake in any of the brain regions studied (r = −0.12 to 0.11, P > 0.15). …

Cognitive phenotypes in Parkinson's disease differ in terms of brainnetwork organization and connectivity

R Lopes, C Delmaire, L Defebvre… - Human brain …, 2017 - Wiley Online Library
… in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be
… The aim of the present study was to investigate changes in whole-brain intrinsic functional …