Changes in plasticity across the lifespan: cause of disease and target for intervention

L Oberman, A Pascual-Leone - Progress in brain research, 2013 - Elsevier
… mechanisms of plasticity change over the lifespan with different slopes of change in different
… If, as we propose, these diseases and disorders stem from aberrant plasticity mechanisms, …

Harnessing plasticity to understand learning and treat disease

MP Kilgard - Trends in neurosciences, 2012 - cell.com
… Recent studies suggest that cortical map plasticity is typically … neural plasticity and suggest
how plasticity might be targeted to … Precisely targeted neural plasticity provides a new avenue …

Phenotypic plasticity and the epigenetics of human disease

AP Feinberg - Nature, 2007 - nature.com
… -risk stratification for targeted intervention and to targeted therapies. … theme to disease
epigenetics is the disruption of phenotypic plasticity — the ability of cells to change their behaviour …

Plasticity diseases

AR Møller - Neurological research, 2009 - Taylor & Francis
… because it is aimed at the cause of the problems, whereas treatment that targets the structures
that produce the symptoms and signs is a form of treatments of the effect of the pathology …

Synaptic plasticity in health and disease: introduction and overview

TVP Bliss, GL Collingridge… - … Transactions of the …, 2014 - royalsocietypublishing.org
We summarize the reviews and research papers submitted by speakers at a discussion
meeting on Synaptic Plasticity in Health and Disease held at the Royal Society, London on 2–3 …

Targeting plasticity with vagus nerve stimulation to treat neurological disease

SA Hays, RL Rennaker, MP Kilgard - Progress in brain research, 2013 - Elsevier
target plasticity due to saturation and poor temporal control. It would be valuable for a targeted
plasticity … successful at specifically targeting plasticity to treat neurological disease. Deep …

Molecular factors mediating neural cell plasticity changes in dementia brain diseases

W Kozubski, K Ong, W Waleszczyk, M Zabel… - … Plasticity, 2021 - Wiley Online Library
… the neural plasticity changes seen in common neurodegenerative diseases from
pathophysiological and clinical points of view and highlight potential molecular targets of disease-…

Alterations in synaptic function and plasticity in Huntington disease

AI SmithDijak, MD Sepers… - Journal of …, 2019 - Wiley Online Library
… at the synapses within these regions, which may ultimately change behaviour and …
plasticity will lend insight into the development of the symptoms of HD, and potential drug targets

Semaphorin function in neural plasticity and disease

RJ Pasterkamp, RJ Giger - Current opinion in neurobiology, 2009 - Elsevier
… for monitoring disease progression, and possibly therapeutic targets to regulate neuronal
connectivity, cell death, and synaptic plasticity following nervous system injury and disease. …

Brain plasticity and pathology in psychiatric disease: sites of action for potential therapy

M Spedding, I Neau, L Harsing - Current Opinion in Pharmacology, 2003 - Elsevier
plasticity at a molecular level has been shown to be rapid and wide-ranging, with the induction
of long-term potentiation (LTP) leading to changes … of many targets involved in plasticity, …