… -negative cancer cells. We report on the degradation in vitro of extracellular matrix by purified
… -D) and by conditioned media prepared from different cell lines. The purified M, 52,000 pro-…

… type IV collagen in breast cancer is primarily due to degradation of the basement … cellular
behavior of mammary cells and breast cancer cells. Non-transformed mammary epithelial cells …

… MMP-2 and MMP-9 are efficient in degrading collagen type IV which is the main composition
of basement membrane that needs to be invaded during tumor progression. Moreover, the …

… metalloproteinase or MMP-14) are concentrated on invadopodial membranes suggesting
that these enzymes are important mediators of invadopodial extracellular matrix degradation […

… Loss of ECM integrity by plasmin facilitates cancer cell spread and plasmin-induced ECM
degradation may be controlled by lipoprotein-A (competitive inhibitor of plasminogen) 56– 58 . …

… In this study, we observed extensive ECM and intercellular junctions in breast cancer patients
… -cell based approach for Rlx expression in tumors mediates tumor ECM degradation and …

… During branching morphogenesis, ECM composition is delicately balanced between
deposition of ECM components and their concomitant degradation by matrix metalloproteinases (…

… for targeting matrix degradation and suppression of cancer cell invasiveness. … degradation,
so it could be a target for cancer therapy. EGF, epidermal growth factor; ERK1/2, extracellular …

… The role of cancer cell synthesis and secretion of enzymes that degrade ECM components
is also emphasized [140,198,199,200,201,202,203]. Invasion of the basement membrane is …

… in 4T1 mammary carcinoma cells reduced collagen degradation in vitro, as assessed by our
live-cell proteolysis assay, and bone metastasis in vivo. Here using this live-cell proteolysis …