Extracellular matrix in angiogenesis: dynamic structures with translational potential

SA Eming, JA Hubbell - Experimental dermatology, 2011 - Wiley Online Library
… We will focus on the interaction of growth factors with extracellular matrix (ECM) components
during the formation of vascular structures in health and disease. Finally, this article will …

Cell–extracellular matrix mechanobiology: forceful tools and emerging needs for basic and translational research

AW Holle, JL Young, KJ Van Vliet, RD Kamm… - Nano …, 2018 - ACS Publications
… mechanical microenvironment as well as the resulting phenotypic changes have great
potential to shape future basic research as well as provide a basis for translational applications. …

Extracellular matrix in intervertebral disc: basic and translational implications

S Zhang, W Liu, S Chen, B Wang, P Wang, B Hu… - Cell and Tissue …, 2022 - Springer
… In healthy mature IVD tissues, extracellular matrix (ECM) complex possesses favorable …
ECM within the IVD provides new insight into potential IVD regeneration strategies. Natural ECM …

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

MC Lampi, CA Reinhart-King - Science translational medicine, 2018 - science.org
… We describe drug development efforts and challenges of individual cellular targets, as
well as the translational potential of available drugs, preclinical studies, and clinical trials. …

The extracellular matrix at a glance

C Frantz, KM Stewart, VM Weaver - Journal of cell science, 2010 - journals.biologists.com
The extracellular matrix (ECM) is the noncellular component present within all tissues and …
are subjected to a myriad of post-translational modifications. Through these physical and …

Translational control of the fibroblast-extracellular matrix association: an application to pulmonary fibrosis

RS Nho, V Polunovsky - Translation, 2013 - Taylor & Francis
… and relentless accumulation of extracellular matrix (ECM). … of the eIF4F-mediated translational
apparatus is an important … In order to find potential therapeutic targets that are effective …

Post-translational modifications of the extracellular matrix are key events in cancer progression: opportunities for biochemical marker development

DJ Leeming, AC Bay-Jensen, E Vassiliadis… - Biomarkers, 2011 - Taylor & Francis
… the potential usefulness of a novel class of biochemical markers, designated neoepitopes.
Neoepitopes are post-translational … by cancer-associated extracellular matrix (ECM) proteins. …

Extracellular matrix molecules: potential targets in pharmacotherapy

H Järveläinen, A Sainio, M Koulu, TN Wight… - Pharmacological …, 2009 - ASPET
The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

[HTML][HTML] The extracellular matrix: Tools and insights for the “omics” era

A Naba, KR Clauser, H Ding, CA Whittaker, SA Carr… - Matrix Biology, 2016 - Elsevier
The extracellular matrix (ECM) is a fundamental component of multicellular organisms that
provides mechanical and chemical cues that orchestrate cellular and tissue organization and …

[HTML][HTML] The biomimetic extracellular matrix: a therapeutic tool for breast cancer research

M Tamayo-Angorrilla, JL de Andrés, G Jiménez… - Translational …, 2022 - Elsevier
… Nevertheless, despite the remarkable potential, the rational design of these biomaterials …
The dECMs not only represent a promising potential for regenerative medicine, but also these …