Expression of membrane-type matrix metalloproteinase in human gastric carcinomas

H Nomura, H Sato, M Seiki, M Mai, Y Okada - Cancer Research, 1995 - AACR
… of membrane-type matrix metalloproteinase (MT-MMP) for activation of the zymogen of
MMP-2 (proMMP-2) in human gastric … activation of proMMP-2 in the human gastric carcinoma. …

… of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library: MT-MMPs form a unique membrane-type subclass in …

T Takino, H Sato, A Shinagawa, M Seiki - Journal of Biological Chemistry, 1995 - ASBMB
… was isolated from a human placenta cDNA library… membrane-type MMP, MT-MMP-2 and
renamed MT-MMP, MT-MMP-1. MT-MMP-1 and −2 are thought to form a distinct membrane-type

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma

XS Puente, AM Pendás, E Llano, G Velasco… - Cancer Research, 1996 - AACR
… to those present in the different membrane-type MMPs (MT-MMPs… isolated from a variety of
human tissues revealed that the … together with its putative membrane localization suggest that …

Membranetype matrix metalloproteinases

M Seiki - Apmis, 1999 - Wiley Online Library
… Assignment of the human genes for membrane-type- I, -2, and -3 matrix metalloproteinases
(MMP14, MMPI5, and MMP16) to 34q12.2, 16q12.2-q21, and 8q21, respectively, by in situ …

Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators

TB Rajavashisth, XP Xu, S Jovinge, S Meisel, XO Xu… - Circulation, 1999 - Am Heart Assoc
… that membrane type 1 MMP (MT1-MMP), a novel transmembrane MMP that activates pro-MMP-2
(gelatinase A), is expressed in human … in normal and atherosclerotic human arteries by …

Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase

T Shimada, H Nakamura, E Ohuchi… - European journal of …, 1999 - Wiley Online Library
… a transmembrane domain, ie membrane type MMPs (MT-MMPs)… reported that a soluble variant
of human MT3-MMP, formed by … only in human ovary [12]. Thus, the substrate specificity of …

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas

H Ueno, H Nakamura, M Inoue, K Imai, M Noguchi… - Cancer research, 1997 - AACR
… Three different membrane-type MMPs (MT-MMPs), MT1-, … In the present study of human
invasive breast carcinomas, we … may play a key role in human breast carcinoma invasion and …

Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling

BG Gálvez, S Matı́as-Román, JP Albar… - Journal of Biological …, 2001 - ASBMB
Matrix metalloproteinases are thought to play an important role in endothelial cell migration
and matrix remodeling. We have used an in vitro wound healing migration model and newly …

Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells

BG Gálvez, S Matías-Román, M Yáñez-Mó… - Molecular biology of …, 2004 - Am Soc Cell Biol
… modulates membrane type 1-matrix metalloproteinase (MT1-MMP) in human endothelial cells
… In this regard, caveolae are revealed as the major MT1-MMP endocytic pathway in human

Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain

Y Wang, AR Johnson, QZ Ye, RD Dyer - Journal of Biological Chemistry, 1999 - ASBMB
Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of
the family of Zn 2+ - and Ca 2+ -dependent MMPs. To investigate the proteolytic capabilities …