… internalizing disorders display exaggerated anticipatory anxiety in response to uncertain or
ambiguous threat. The … disorders as they were found to display relatively normal responses to …

… uncertain, but not predictable, threat is positively correlated with a family history of alcohol
use disorder … The increased reactivity to uncertain threat evidenced in individuals with AUD …

… Those with internalizing disorders had heightened insula activation to U-threat. … U-threat
is temporally uncertain and of varying intensity, frequency and/or duration. It involves situations …

… Study 2 recruited biological sibling pairs, and so instances where both siblings met criteria
for a current internalizing disorder, only one individual was chosen at random to be included …

… suppression to unpredictable threat. The maternal internalizing spectrum was positively
associated with adolescent startle potentiation to unpredictable threat and P300 suppression to …

… sensitized to other forms of ambiguous or uncertain threat, regardless of its true potential to
… individuals were not required to have a DSM diagnosis of internalizing disorders. Instead, …

… directly targets reactivity to uncertain threats/stressors than … to U-threat as a potential
organizing ‘Potential Threat’ construct … report) for certain internalizing disorders and an objective, …

… dampens physiological reactivity to uncertain (but not certain) threat, suggesting that use of
… internalizing disorder symptoms in our models to examine whether intolerance of uncertainty …

… Individuals with a lifetime history of an internalizing disorder exhibited greater startle
magnitude during the task compared with individuals without a history of an internalizing disorder. …

… Intolerance of uncertainty (IU) is a transdiagnostic risk factor for internalizing disorders.
Prior work has found that IU may be associated with either increased reactivity to threat or, …