… The tissue inhibitors of metalloproteinases 1–4 (TIMPs) have … ), an important basement
membrane-degrading MMP pivotal to … A and the active site of membrane type-1 (MT1) MMP. This …

… MT1-MMP forms a complex on the cell membrane with its physiological protein inhibitor,
tissue inhibitor of metalloproteinases-2 (TIMP-2). Here we show that, in addition to extracellular …

… It has been proposed that tissue inhibitor of metalloproteinase-2 (TIMP-2), in stoichiometric
… activated membrane type 1-matrix metalloproteinase 1 (MT1-MMP) on the plasma membrane…

… membranetype matrix metalloproteinase 1(MT-MMP-1) were examined by express ing in
COS-1 cells a deletion mutant of MT-MMP-1 lacking the transmembrane … with tissue inhibitor of …

… extracellular matrix components is held in check by the tissue inhibitors of metalloproteinases
(TIMPs). The binary complex of TIMP-2 and membrane-type-1 MMP (MT1-MMP) forms a …

… We report here that a soluble active form of membranetype-2 … the type- 1 at rates which
are dependent on the concentration of the proenzyme. Activation is inhibited by tissue inhibitors …

… Activation could be inhibited by antibodies against MT1-MMP, by addition of recombinant
tissue inhibitor of metalloproteinases (TIMP)-2 and by inhibition of MT1-MMP cleavage. MT1-…

… a subgroup of membrane-… inhibition by members of the tissue inhibitor of metalloproteinase
(TIMP) family. Here we investigated the processing, catalytic activity, and TIMP inhibition …

… MMP-2 (gelatinase A) and membrane type 1 MMP (MT1-MMP), an activator of the zymogen
of MMP-2, proMMP-2, together with tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-…

… extracellular matrix is the soluble and membrane-associated matrix metalloproteinases. …
membrane type 1 matrix metalloproteinases (MT1-MMP) in the presence of the tissue inhibitor of …