Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption

P Hou, T Troen, MC Ovejero, T Kirkegaard… - Bone, 2004 - Elsevier
… of MMP-12 in these processes. In conclusion, we found that osteoclasts are able to express
MMP-12, but MMP-12 … The fact that none of the MMPs identified so far in osteoclasts appears …

Development of selective inhibitors and substrate of matrix metalloproteinase-12

L Devel, V Rogakos, A David, A Makaritis… - Journal of Biological …, 2006 - ASBMB
matrix metalloproteinases (MMPs). We identified two phosphinic peptides with Ki values of
0.19 and 4.4 nm toward MMP-12 … potent toward the other MMPs tested. These highly selective …

Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma

KTP Ng, X Qi, KL Kong, BYY Cheung, CM Lo… - European journal of …, 2011 - Elsevier
Matrix metalloproteinase-12 (MMP-12), previously identified from our animal model, is … and
prognostic value of MMP-12 expression in human HCC. MMP-12 mRNA level of 139 pairs of …

Causal effect of MMP-1 (matrix metalloproteinase-1), MMP-8, and MMP-12 levels on ischemic stroke: a mendelian randomization study

J Cárcel-Márquez, N Cullell, E Muiño… - 2021 - Am Heart Assoc
Background and Purpose: MMP (matrix metalloproteinase) levels have been widely associated
with ischemic stroke risk and poststroke outcome. However, their role as a risk factor or …

Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13–dependent fibrosis

SK Madala, JT Pesce, TR Ramalingam… - The Journal of …, 2010 - journals.aai.org
… and extracellular matrix (ECM) remodeling. Matrix metalloproteinases (MMP) are important
regulators of the ECM by regulating cellular inflammation, extracellular matrix deposition, and …

Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E–deficient mice against atherosclerotic media destruction but differentially …

A Luttun, E Lutgens, A Manderveld, K Maris, D Collen… - Circulation, 2004 - Am Heart Assoc
… proteinases of the matrix metalloproteinase (MMP) family in … proteolytic activation of MMPs.
However, the role of specific … In this study we analyzed the role of MMP-9 and MMP-12 in …

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

DJ Marchant, CL Bellac, TJ Moraes, SJ Wadsworth… - Nature medicine, 2014 - nature.com
… Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix
metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the …

Matrix metalloproteinases in COPD

A Churg, S Zhou, JL Wright - European Respiratory Journal, 2012 - Eur Respiratory Soc
… Factors that control matrix metalloproteinase (MMP)-12 production and secretion by alveolar
macrophages after smoke exposure. Because of the numerous different mediators that …

An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice

JEA Wells, TK Rice, RK Nuttall… - Journal of …, 2003 - Soc Neuroscience
… of matrix metalloproteinases (MMPs) in acute spinal cord injury (SCI). Transcripts encoding
22 of the 23 known mammalian MMPs … levels of multiple MMPs, MMP-12 was increased 189-…

Matrix metalloproteinase (MMP)12 expression has a negative impact on sensorimotor function following intracerebral haemorrhage in mice

JEA Wells, J Biernaskie, A Szymanska… - European Journal of …, 2005 - Wiley Online Library
… We investigated the role of matrix metalloproteinases (MMPs) in a mouse model of intracerebral
… Transcripts encoding nine of the 23 known mammalian MMPs were measured. MMP-12