… However, the mechanisms used by invading tumor cells to evade collagen-induced … type-1
matrix metalloproteinase (MT1-MMP/MMP-14) confers breast cancer cells with the ability to …

… and regulators in HC1806 breast cancer cells [64]. … Thr567 phosphorylation increased
breast cancer cell type I … the MT1-MMP CT Thr567 enhances ovarian cancer aggregation (…

… When fluorescently labeled human MCF-7 breast carcinoma cells, a well-differentiated cancer
cell line that displays minimal invasive activity in mouse model systems (3, 4), are cultured …

… with MT1-MMP trafficking in molecular details is important for cancer cell biology and …
in situ–to–invasive transition of breast cancer (BC), it was recently reported that silencing of …

… expression levels of MT1-MMP, MMP-2 and -9 in the aggressive breast cancer phenotype
IBC … MT1-MMP correlates with expression and activation of MMP-2 and MMP-9. We found that …

… cell-derived MT1-MMP by carcinoma cells. In the present study, MT1-MMP was observed
in both carcinoma and stromal cells, as well as in both the membrane of the cancer cells and …

… However, the role of integrin αvß3 in the MMP-… MMP-2 activation pathway in MCF7 breast
carcinoma cells is likely to be a two-cell receptor-mediated event that involves both MT1-MMP …

… , we demonstrated the identical inverse relationship between MMP-2 and -9 transcript and
… MT1-MMP positive breast cancer cells. To further analyze the relationship between MMP-2 …

… tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization,
processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells. J. Biol. …

… , the researchers analyzed its contribution to MT1-MMP trafficking. siRNA-mediated … ) in
MT1-MMP–expressing breast cancer cells reduced MT1-MMP exocytosis and tumor cell invasion…