Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

C Lodillinsky, L Fuhrmann, M Irondelle, O Pylypenko… - Oncogene, 2021 - nature.com
… components of breast tumor cells relative … MT1-MMP levels in the invasive components of
breast tumors, particularly in aggressive histological grade III and triple-negative breast cancers

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

IR Macpherson, E Rainero, LE Mitchell… - Journal of cell …, 2014 - journals.biologists.com
… Here, we show that in two estrogen receptor (ER)-negative breast cancer cell lines, … matrix
metalloproteinase MT1-MMP (also known as MMP14). In MDA-MB-231 cells, MT1-MMP and …

Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function

A Castagnino, A Castro-Castro, M Irondelle… - Oncogene, 2018 - nature.com
… of breast cancer cells. We report that expression of coronin 1C is elevated in invasive human
breast cancers, correlates positively with MT1-MMP … prognostic factor in breast cancer. We …

Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell …

CI Kung, CY Chen, CC Yang, CY Lin… - Oncology …, 2012 - spandidos-publications.com
MT1-MMP expression to facilitate breast cancer cell migration. … MT1-MMP expression in
breast cancer cells. In order to validate the relevance of cell migration and HA-induced MT1-MMP

Epigenetic control of the invasion-promoting MT1-MMP/MMP-2/TIMP-2 axis in cancer cells

AV Chernov, NE Sounni, AG Remacle… - Journal of Biological …, 2009 - ASBMB
… an epigenetic analysis of the MT1-MMP, MMP-2, and TIMP-2 gene promoters in highly
migratory glioblastoma cells and in low migratory breast carcinoma MCF-7 cells. We determined, …

Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1MMP, MMP2 and MMP9 in human glioblastomas

C Munaut, A Noël, O Hougrand… - … journal of cancer, 2003 - Wiley Online Library
… local proteolysis involving matrix metalloproteinases (MMPs). Recent studies have shown …
MMPs. We reported previously that the expression of MT1-MMP in human breast cancer cells

MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease

L Szabova, K Chrysovergis, SS Yamada, K Holmbeck - Oncogene, 2008 - nature.com
… Here, we demonstrate that genetically induced mammary cancer develops in an MT1-MMP-deficient
background more rapidly than in a wild-type background, however, with a …

Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells

M Polette, C Gilles, B Nawrocki-Raby, J Lohi… - Cancer research, 2005 - AACR
… We showed that the expression of MT1-MMP in invasive breast tumor cell lines correlates
with the absence of occludin and with a cytoplasmic localization of ZO-1. In contrast, …

Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP): the role of the cytoplasmic tail Cys574, the active site Glu240, and furin cleavage motifs …

DV Rozanov, EI Deryugina, BI Ratnikov… - Journal of Biological …, 2001 - ASBMB
… The mutants were expressed in MCF7 breast carcinoma cells that are deficient in both
MMP-2 and MT1-MMP. Our results supported the existence of MT1-MMP oligomers and …

… and MT1-MMP expression levels are determinant for triggering BIK-mediated apoptosis by 3D type I collagen matrix in invasive basal-like breast carcinoma cells

C Saby, G Collin, M Sinane, E Buache… - Frontiers in …, 2019 - frontiersin.org
… apoptosis observed in the luminal breast cancer cell line MCF-7, we then investigated
the effect of MT1-MMP depletion on DDR1 expression profile in the basal-like cell line MDA-MB-…