Timp2 binding with cellular MT1MMP stimulates invasionpromoting MEK/ERK signaling in cancer cells

NE Sounni, DV Rozanov, AG Remacle… - … journal of cancer, 2010 - Wiley Online Library
… The results we describe here represent the continuation of our published study in which
we have used breast carcinoma MCF-7 cells which were stably transfected and, as a result, …

NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP

Y Lin, G Chang, J Wang, W Jin, L Wang, H Li… - Experimental cell …, 2011 - Elsevier
breast cancer cell line MCF-7 was preserved by our laboratory. The highly invasive human
breast cancer cell … MCF-7 and MDA-MB-231 cells were cultured in RPMI-1640 medium (Gibco…

[HTML][HTML] Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer

M Zhang, X Teng, X Guo, Z Li, J Han, L Yao - The Breast, 2013 - Elsevier
MT1-MMP mRNA expression in the breast cancer was significantly higher than in the normal
breast tissue (p < 0.05), the levels of MT1-MMP … , and histological type of breast cancer. …

SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway

G Wan, Y Liu, J Zhu, L Guo, C Li, Y Yang, X Gu… - Cellular …, 2019 - Elsevier
… We assessed 5 typical cancer cell lines—MCF7 for breast cancer, HCT116 for colorectal …
on cancer cell invasion through controlling MT1-MMP expression. As to how MT1-MMP

MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells

KL Sodek, MJ Ringuette, TJ Brown - British journal of cancer, 2007 - nature.com
… the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis
of MT1-MMP expressed in breast carcinoma cells. J Biol Chem 276: 25705–25714 …

Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT

W Li, S Li, L Deng, S Yang, M Li, S Long, S Chen, F Lin… - Tumor Biology, 2015 - Springer
… a selective MT1-MMP inhibitor reduced cancer cell motility … cell carcinoma, oral carcinoma,
and breast carcinoma cell line [6]… of MT1-MMP can facilitate prostate cancer cell invasion and …

[HTML][HTML] Target engagement of an anti-MT1-MMP antibody for triple-negative breast cancer PET imaging and beta therapy

N Magro, M Oteo, E Romero… - Nuclear Medicine and …, 2024 - Elsevier
cancer cells for the specific delivery of ionizing radiation. Given that MT1-MMP is overexpressed
in MDA-MB-231 cells … mediated by MT1-MMP binding, TRT against MT1-MMP may have …

Novel roles of MT1-MMP and MMP-2: beyond the extracellular milieu

DV Maybee, NL Ink, MAM Ali - International journal of molecular sciences, 2022 - mdpi.com
… Likewise, TIMP-1 was found to translocate to the nucleus of human MCF-7 breast
carcinoma cells after binding to the cell surface [103]. This response of TIMP-1 immediately …

Membrane type 1 matrix metalloproteinase–mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation

G Su, SA Blaine, D Qiao, A Friedl - Cancer research, 2008 - AACR
… We hypothesize that fibroblast MT1-MMP stimulates T47D carcinoma cell growth indirectly
by cleaving and releasing Sdc1. If this model is correct, one would anticipate that adding …

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

J Suojanen, T Salo, E Koivunen, T Sorsa… - Cancer biology & …, 2009 - Taylor & Francis
… 10) and to further analyze possible effects of PG on the MDA-MB-435 breast cancer cell
line we studied cell transmigration and Matrigel-invasion. PG had no effect on their migration …