… , relative to other breast cancer subtypes. Together, our findings established that MT1-MMP
activity in breast tumors is essential for BVI, but not LVI, and that MT1-MMP should be further …

… We further investigated the presence of the MT1MMP mRNA transcript in Con A treated and
untreated HBC cell lines with differential MMP-2 activation potentials. Northern analyses for …

… For example, primary breast cancer tumors in MT1-MMP-deficient … of MT1-MMP up-regulation
with patients with metastatic breast cancer, and the inverse correlation of high MT1-MMP …

MT1â•’MMP expression promotes tumor growth and angiogenesis through an upâ•’regulation
of vascular endothelial growth Page 1 MT1-MMP expression promotes tumor growth and …

… Finally, we observed that, in breast tumors, increased total phosphorylated aPKCι correlated
with high cortactin expression and phosphorylation at the aPKCι-specific site in the actin-…

… Here, we demonstrate that genetically induced mammary cancer develops in an MT1-MMP-deficient
background more rapidly than in a wild-type background, however, with a …

… MT1-MMP, resulting in MT1-MMP-mediated PDAC cell invasion of collagen [90]. Snail1
increases the expression of MT1-MMP and breast carcinoma basement membrane invasion [91]. …

… mammary carcinoma (IMC), to show that the metastatic cell line produces little MT1-MMP
protein, consistent with our conclusions using MCF-7 and MDA-MB 231 breast cancer cells. …

… and MMP-2 activation without changes in MT1-MMP expression. Our studies suggest that
hypoxic tumor microenvironments promote breast cancer invasion through an MT1-MMP-…

… Brown PD, Bloxidge RE, Anderson E, Howell A: Expression of activated gelatinase in human
invasive breast carcinoma. Clin Exp Metastasis 11: 183–189, 1993 17. Brown PD, Bloxidge …