… ), and they can be subgrouped into 15 soluble-type and 5 membrane-type MMPs (MT-MMPs).
With the exception of stromelysin 3 (MMP-11), soluble-type MMPs are secreted as …

… First, MT4-MMP is anchored to the membrane by a GPI anchor, a feature only shared with
MT6-MMP, and second, unlike most MT-MMPs, MT4-MMP is inefficient in the activation of pro-…

… which membrane-type 4 matrix metalloproteinase (MT4-MMP), a membrane-anchored MMP
… breast adenocarcinoma MDA-MB-231 cells overexpressing or not MT4-MMP. We found that …

… Transmembrane-type MT-MMPs including MT1, MT2, MT3, MT5-MMPs have a … linker-2,
and GPI-anchored type MT-MMPs including MT4-MMP and MT6-MMP have a short hydrophobic …

… At present, the profile of MT4-MMP forms and whether MT4-MMP is able to generate
homodimers has not been reported. In this study, we examine the profile of MT4-MMP expressed by …

… However, we found MT4MMP protein to be abundantly … type that abundantly expresses the
MT4-MMP protein allowing us to study its synthesis and processing in an authentic cell type. …

… MMPs are secreted as soluble enzymes, six of them are membrane-type MMPs (MT-MMP), …
by exposing the membranes to primary antibody: anti-human MT4-MMP sheep polyclonal …

… of matrix metalloproteinases (MMPs) play a pivotal role. The MMPs evolved to accomplish
their … The membrane type-MMPs (MT-MMPs) incorporated membrane anchoring domains that …

… of MT4MMP were mainly found in brain, leukocytes, colon, ovary, and testis. In addition,
MT4-MMP … Here we report that MT4-MMP catalytic domain does not activate progelatinase A and …

… the first membranetype MMP (4), three distinct MT-MMP genes … - (4, 5, 7), MT2- (8, 12), MT3-
(6, 10) and MT4-MMP (9). MT-… their amino acid sequence, MT4-MMP is relatively distant from …