Objectives Antidepressant prescribing almost doubled in the Netherlands between 1996
and 2012, which could be accounted for by longer continuation after the first prescription …

Background The benefits and risks of augmenting or switching antidepressants in older
adults with treatment-resistant depression have not been extensively studied. Methods We …

BACKGROUND: In a real-life setting, differences across newer antidepressants in patterns
of use remain poorly explored, particularly in the older patients despite the high prevalence …

Background We aimed to describe patterns of use and characteristics of 10 commonly used
antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden …

In general, the pharmacological treatment of non-psychotic major depressive disorder in old
age is only partially successful, with only approximately 50% of older depressed adults …

Purpose Antidepressant drug use increases worldwide. It is pivotal to closely monitor the
use of antidepressants and to determine in what subpopulations the rise is most substantial …

Background Antidepressants are one of the most commonly prescribed drugs in primary
care. The rise in use is mostly due to an increasing number of long-term users of …

Objective Evidence from clinical trials comparing effectiveness and safety of
pharmacological strategies in older adults unresponsive to first-line antidepressants is …

Despite marked increases in antidepressant drug prescriptions over the last 3 decades, the
burden and disability attributed to major depression are still on the rise. This calls into …

Objective To establish the efficacy and tolerability of continuing treatment with
antidepressants in preventing relapses and recurrences in elderly depressed patients and to …