Objectives In diabetic nephropathy (DN), hypoxiainducible factor1α (HIF1α) activation in
tubular cells plays an important protective role against kidney injury. The effects may occur …

Hypoxia-inducible factor (HIF)-1 mediates hypoxia-and chronic kidney disease–induced
fibrotic events. Here, we assessed whether HIF-1 blockade attenuates the manifestations of …

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …

OBJECTIVE Chronic hypoxia has been recognized as a key regulator in renal
tubulointerstitial fibrosis, as seen in diabetic nephropathy, which is associated with the …

Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a
central mechanism for the development of diabetes complications. Recently, hypoxia has …

Increasing HIF activity in the diabetic kidney may possess a novel target for treatment of
DKD by improving kidney oxygen homeostasis. However, HIF-mediated glomerulosclerosis …

Studies over the last two decades have established tubulointerstitial hypoxia as a final
common pathway leading to end-stage kidney disease (ESKD). Chronic kidney disease …

Overactivation of hypoxia-inducible factor (HIF)-1α is implicated as a pathogenic factor in
chronic kidney diseases (CKD). However, controversy exists regarding the roles of HIF-1α in …

Hypoxia and oxidative stress are the common causes of various types of kidney injury.
During recent years, the studies on hypoxia inducible factor(HIF) 1 attract more and more …

Type 2 diabetes (T2D) impairs hypoxia-inducible factor (HIF) 1α activation, a master
transcription factor that drives cellular adaptation to hypoxia. Reduced activation of HIF1α …