Abstract MT1-MMP (membrane type-1 matrix metalloproteinase), otherwise known as
MMP14 is a proteolytic enzyme known to be involved in degradating extracellular matrix and …

Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct
membrane-associated MMPs. Although the contribution of MT1-MMP during different steps …

Activation of the zymogen of matrix metalloproteinase 2 (proMMP-2, progelatinase A)
possibly is one of the key steps in invasion and metastasis of various human carcinomas …

MT4-MMP (or MMP17) belongs to the Membrane-Type Matrix Metalloproteinase (MT-MMP)
family. This family of proteases contributes to extracellular matrix remodeling during several …

BACKGROUND: Breast cancer is the most common cancer affecting women in the world
today. Matrix metalloproteinases (MMPs) are a family of endopeptidases that can degrade …

A new member of the matrix metalloproteinase (MMP) family of enzymes has been cloned
from a human breast carcinoma cDNA library. The isolated cDNA contains on open reading …

Crucial event in the metastasis of cancer cells is the secretion of matrix metalloproteinases
(MMPs), which are responsible for the degradation of extracellular matrix (ECM). Among …

Inflammatory breast cancer (IBC) represents the most aggressive form of breast cancer,
characterized by rapid progression, involvement of dermal lymphatic emboli and extensive …

Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis
and invasion through the degradation of extracellular matrix (ECM). MT1MMP (membrane …

To investigate the role of membrane-type matrix metalloproteinase-1 (MT1-MMP) in
mammary gland development and tumorigenesis, transgenic mice overexpressing MT1 …