The historical and genetic foundations of our current understanding of schizophrenia are
reviewed, as are the present and future directions for research. Genetic epidemiological …

Multiple research paradigms have provided evidence for a substantial genetic component in
the etiology of schizophrenic disorders. This article reviews the major research strategies …

Abstract In the “Special Report on Schizophrenia” published in the Schizophrenia Bulletin in
1987, the genetic basis of schizophrenia was reviewed. Here, we provide our perspective on …

Family, twin, and adoption studies have firmly established the genetic basis for a majority of
cases of schizophrenia. Several other psychiatric disorders probably represent alternative …

Sociopolitical and ideological attacks on the various genetically oriented programs of
research into the causes of schizophrenia, even when wellmotivated to prevent genetic …

Abstract Purpose of Review We review recent developments on risk factors in
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …

In recent years schizophrenia has been assumed to be largely a genetic disease with
heritability estimates, derived primarily from family and twin studies, of 80%–85%. However …

Although a decade has passed since the genetics of schizophrenia was examined for the
Schizophrenia Bulletin, the epigenetic puzzle of schizophrenia has not yielded its secrets to …

▪ Abstract A combination of genetic susceptibility and environmental perturbations appear to
be necessary for the expression of schizophrenia. In addition, the pathogenesis of the …

The rapid pace of advance in genetics research has increased greatly our understanding of
the cause and pathogenesis of a range of common human diseases. Genetic research has …