Extracellular matrix (ECM) remodeling is important during bone development and repair.
Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone …

The assembly and degradation of extracellular matrix (ECM) molecules are crucial
processes during bone development. In this study, we show that ECM remodeling is a …

The regeneration of adult skeletal tissues requires the timely recruitment of skeletal
progenitor cells to an injury site, the differentiation of these cells into bone or cartilage, and …

The matrix metalloproteinase (MMP) family of extracellular proteases performs crucial roles
in development and repair of the skeleton owing to their ability to remodel the extracellular …

Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral
endopeptidases, is expressed in the skeleton during embryonic development and is highly …

Like bone mass, bone quality is specified in development, actively maintained postnatally,
and disrupted by disease. The roles of osteoblasts, osteoclasts, and osteocytes in the …

Vascular and cellular invasion into the cartilage is a critical step in the fracture healing.
Matrix metalloproteinase-13 (MMP-13) is a member of the zinc-dependent endopeptidase …

In fracture healing, a large amount of cartilage is formed, then rapidly replaced by osseous
tissue. This process requires the transition of extracellular matrix component from type II to …

Matrix metalloproteinase (MMP)-13 (an interstitial collagenase also called collagenase 3) is
involved in degradation of extracellular matrix in various tissues. Using …

Matrix metalloproteinases (MMPs) are capable of processing certain components of bone
tissue, including type 1 collagen, a determinant of the biomechanical properties of bone …