Amyloid precursor protein (APP) derived amyloid beta (Aβ) peptides have been extensively
investigated in Alzheimer's disease pathology of the brain. However, the function of full …

The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer's
disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are …

Amyloid precursor protein (APP) can be proteolytically processed along two pathways, the
amyloidogenic that leads to the formation of the 40–42 amino acid long Alzheimer …

The βamyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the βamyloid protein (Aβ) of Alzheimer's disease. However, the normal …

The amyloid precursor protein (APP) can be cleaved by a β-secretase to generate a β-
amyloid peptide, which has been implicated in the pathogenesis of Alzheimer's disease …

γSecretasedependent regulated intramembrane proteolysis of amyloid precursor protein
(APP) releases the APP intracellular domain (AICD). The question of whether this domain …

The amyloid-beta (Aβ) peptide is the derivative of amyloid precursor protein (APP)
generated through sequential proteolytic processing by β-and γ-secretases. Excessive …

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …

It was previously shown by us and by others that activation of muscarinic acetylcholine
receptors evoke amyloid precursor protein (APP) secretion in various cell lines. Here we …

The amyloid protein precursor (APP) can be processed via several alternative processing
pathways, α-secretase processing by cleavage within the amyloid β-peptide domain of APP …