Introduction: Schizophrenia is one of the most serious mental disorders. Its treatment
remains challenging, as existing antipsychotic antidopaminergic medications improve …

Schizophrenia remains one of the most severe medical diseases. Current dopamine
modulating first-generation and second-generation antipsychotics target mainly positive …

Schizophrenia is a chronic and often severe mental disorder for which antipsychotic drugs
are the cornerstone of treatment. Although the essential mechanism of action of these drugs …

The currently available antipsychotics mostly treat the positive symptoms of schizophrenia
and have at least one adverse effect as a potential liability. Encouraging data suggest …

Introduction: For over half a century now, the dopamine hypothesis has provided the most
widely accepted heuristic model linking pathophysiology and treatment in schizophrenia …

Schizophrenia is a debilitating syndrome consisting of several symptom dimensions
(positive and negative symptoms; cognitive and mood disturbances) with a large unmet …

Despite the expansion of available antipsychotic drugs over the past 50 years, functional
outcomes for individuals with schizophrenia have not markedly improved. These agents are …

Publisher Summary Schizophrenia is typically a lifelong and often devastating, but relatively
common (life-time risk of 1%), psychiatric disorder, which often begins in late adolescence or …

Background Schizophrenia is a disabling disorder that profoundly affects functioning and
quality of life. While available antipsychotics have improved outcomes for patients with …

Schizophrenia is a complex disorder of varied etiology, manifesting symptoms that can differ
between patients and change throughout an individual's lifespan. Antipsychotic drugs have …