In osteoporosis, bone loss is accompanied by greater adiposity in the marrow. Given the
cellular proximity within the bone marrow, we wondered whether adipocytes might have a …

A reciprocal relationships between osteogenesis and adipogenesis has been observed in
vitro and in vivo, and mechanical stretch has been believed to be a regulating factor of osteo …

Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source
for tissue engineering and regenerative medicine. We compared human bone marrow …

Genetic mutations in the LRP5 gene affect Wnt signaling and lead to changes in bone mass
in humans. Our in vivo and in vitro results show that activated mutation T253I of LRP5 …

Bones adapt to accommodate the physical forces they experience through changes in
architecture and mass. Stem cells differentiate into bone-forming osteoblasts, and …

Human adipose stem cells (hASCs) have been recently used to treat bone defects in clinical
practice. Yet there is a need for more optimal scaffolds and cost-effective approaches to …

Objective To investigate the role of obesity on the bone marrow microenvironment and
evaluate its possible impact on the adipogenic potential of mesenchymal stem cells (MSC) …

Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the
most promising alternative to autologous bone grafting. However, one of the limiting factors …

Bone marrow stromal cells can undergo adipogenesis or osteoblastogenesis in vitro and in
vivo. This review explores the stromal cell's differentiation plasticity in the context of …

Osteoblasts and adipocytes originate from a common progenitor, which arises from bone
marrow mesenchymal stroma/stem cells (mMSC). Aging causes a decrease in the number of …