Distraction osteogenesis (DO) successfully induces large-scale skeletal tissue regeneration,
but it involves an undesirably long treatment period. A high-speed DO mouse model (H-DO) …

Bone morphogenetic proteins (BMPs) are believed to be the most potent osteoinductive
factors. However, BMPs are highly pleiotropic molecules and their supra-physiological high …

Mesenchymal progenitor cells play a vital role in bone regenerative medicine and tissue
engineering strategies. To be clinically useful osteoprogenitors should be readily available …

Tissue engineering using mesenchymal stem cells (MSCs) holds great promise for
regenerating critically sized bone defects. While the bone marrow-derived MSC is the most …

Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In
this study, we investigated differentiation-induced transformations in MSC cellular and …

Age-related skeletal degeneration in patients with osteoporosis is characterized by
decreased bone mass and occurs concomitant with an increase in bone marrow adipocytes …

There is great interest in how bone marrow derived stem cells make fate decisions.
Numerous studies have investigated the role of individual growth factors on mesenchymal …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

The majority of conditions associated with bone loss, including aging, are accompanied by
increased marrow adiposity possibly due to shifting of the balance between osteoblast and …