A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism
K Inoue, Y Mikuni-Takagaki, K Oikawa, T Itoh… - Journal of Biological …, 2006 - ASBMB
Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …
Matrix metalloproteinase–13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance
Like bone mass, bone quality is specified in development, actively maintained postnatally,
and disrupted by disease. The roles of osteoblasts, osteoclasts, and osteocytes in the …
and disrupted by disease. The roles of osteoblasts, osteoclasts, and osteocytes in the …
A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells
TL Andersen, M del Carmen Ovejero, T Kirkegaard… - Bone, 2004 - Elsevier
Genetic diseases and knockout mice stress the importance of matrix metalloproteinases
(MMPs) in skeletal turnover. Our study aims at clarifying which MMPs are expressed by …
(MMPs) in skeletal turnover. Our study aims at clarifying which MMPs are expressed by …
Destroy to rebuild: the connection between bone tissue remodeling and matrix metalloproteinases
E Hardy, C Fernandez-Patron - Frontiers in physiology, 2020 - frontiersin.org
Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …
process by which old bone is replaced and localized bone defects are repaired to renew the …
Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2
S Lieu, E Hansen, R Dedini… - Disease models & …, 2011 - journals.biologists.com
The matrix metalloproteinase (MMP) family of extracellular proteases performs crucial roles
in development and repair of the skeleton owing to their ability to remodel the extracellular …
in development and repair of the skeleton owing to their ability to remodel the extracellular …
Matrix metalloproteinases in bone development and pathology: current knowledge and potential clinical utility
Matrix metalloproteinases (MMPs) are degrading enzymes that have a pivotal function in
extracellular matrix remodeling. More than half of the MMP members are expressed by bone …
extracellular matrix remodeling. More than half of the MMP members are expressed by bone …
How proteases regulate bone morphogenesis
N Ortega, D Behonick, D Stickens… - Annals of the New York …, 2003 - Wiley Online Library
Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix
(ECM), as well as many nonECM molecules. MMPs participate in (1) degradation of ECM to …
(ECM), as well as many nonECM molecules. MMPs participate in (1) degradation of ECM to …
Differential effects between the loss of MMP2 and MMP9 on structural and tissuelevel properties of bone
Matrix metalloproteinases (MMPs) are capable of processing certain components of bone
tissue, including type 1 collagen, a determinant of the biomechanical properties of bone …
tissue, including type 1 collagen, a determinant of the biomechanical properties of bone …
[HTML][HTML] Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis
X Li, L Jin, Y Tan - Molecular Medicine Reports, 2021 - spandidos-publications.com
Abstract Matrix metalloproteinase 2 (MMP2) is a well‑characterized protein that is
indispensable for extracellular matrix remodeling and other pathological processes, such as …
indispensable for extracellular matrix remodeling and other pathological processes, such as …
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
D Stickens, DJ Behonick, N Ortega, B Heyer… - 2004 - journals.biologists.com
The assembly and degradation of extracellular matrix (ECM) molecules are crucial
processes during bone development. In this study, we show that ECM remodeling is a …
processes during bone development. In this study, we show that ECM remodeling is a …
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