Membrane-type 1 matrix metalloproteinase (MT1-MMP) is expressed highly in mineralizing
tissues including bones and teeth. Mice deficient in MT1-MMP (m/m) display severe defects …

Knowledge about the regulation of cell lineage-specific expression of extracellular matrix
metalloproteinases is limited. In the present work, the murine matrix metalloproteinase 9 …

Cells must alter their expression profiles and morphological characteristics but also reshape
the extracellular matrix (ECM) to fulfill their functions throughout their lifespan. Matrix …

Recessive inactivating mutations in human matrix metalloproteinase 2 (MMP2, gelatinase A)
are associated with syndromes that include abnormal facial appearance, short stature, and …

Endochondral bone formation requires the action of cells of the chondrocytic and
osteoblastic lineage, which undergo continuous differentiation during this process. To …

Matrix metalloproteinase (MMP)-13 (an interstitial collagenase also called collagenase 3) is
involved in degradation of extracellular matrix in various tissues. Using …

The matrix metalloproteinase (MMP) family (∼ 25 members in mammals) has been
implicated in extracellular matrix remodeling associated with embryonic development …

Gene ablation in mice offers a powerful tool to assay in vivo the role of selected molecules.
Numerous new mouse models of matrix metalloproteinases (MMP) deficiency have been …

Multiple myeloma (MM) cells secrete osteoclastogenic factors that promote osteolytic
lesions; however, the identity of these factors is largely unknown. Here, we performed a …

Objective To investigate the role of matrix metalloproteinase 13 (MMP13; collagenase 3) in
osteoarthritis (OA). Methods OA was surgically induced in the knees of MMP13–knockout …