Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family
of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding …

The regeneration of adult skeletal tissues requires the timely recruitment of skeletal
progenitor cells to an injury site, the differentiation of these cells into bone or cartilage, and …

Extracellular proteolysis and turnover are core processes of tissue homeostasis. The
predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase …

We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic
bone resorption by facilitating migration of osteoclastic cells toward bone surface through …

[Frontiers in Bioscience 11, 1702-1715, May 1, 2006] 1702 Matrix metalloproteinases: role in
skeletal development and growth pla Page 1 [Frontiers in Bioscience 11, 1702-1715, May 1 …

Like other tissue injuries, bone fracture triggers an inflammatory response, which plays an
important role in skeletal repair. Inflammation is believed to have both positive and negative …

Membrane type 1-matrix metalloproteinase (MT1-MMP) is a major mediator of collagen I
degradation. In human samples, we show that prostate cancer cells in skeletal metastases …

The gelatinases, a subgroup of the matrix metalloproteinases (MMPs) superfamily are
composed of two members; MMP2 and MMP9. They are known to degrade gelatin among …

Introduction 3. Regulation and Function of MMPs 3.1. Regulation of MMP synthesis 3.2.
MMP structure and function studies 4. MMPs in health and disease 4.1. Skeletal …

Cartilage, bone and the interstitial stroma, composed largely of the interstitial collagens,
types I, II and III, are remodelled by three members of the metalloproteinase (MMP) family …