Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice

JD Bartlett, Z Zhou, Z Skobe, JM Dobeck… - Connective tissue …, 2003 - Taylor & Francis
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is expressed highly in mineralizing
tissues including bones and teeth. Mice deficient in MT1-MMP (m/m) display severe defects …

Expression and localization of membrane type 1 matrix metalloproteinase in tooth tissues

C Caron, J Xue, JD Bartlett - Matrix Biology, 1998 - Elsevier
Matrix metalloproteinases (MMPs) have been detected in forming dental enamel and are
thought to play an important role during enamel biomineralization. Membrane-type 1 matrix …

Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice

W Beertsen, K Holmbeck, A Niehof… - Connective tissue …, 2003 - Taylor & Francis
To study whether eruption of teeth and root growth require remodeling of collagen in the
peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme …

Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption

H Xu, TN Snider, HF Wimer, SS Yamada, T Yang… - Matrix Biology, 2016 - Elsevier
Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a transmembrane zinc-
endopeptidase that breaks down extracellular matrix components, including several …

On the role of MT1MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth

W Beertsen, K Holmbeck, A Niehof… - European journal of …, 2002 - Wiley Online Library
Although the connective tissues of the periodontium are subject to a high turnover rate, no
conclusive evidence has yet emerged that periodontal collagen turnover is essential for the …

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

K Holmbeck, P Bianco, J Caterina, S Yamada… - Cell, 1999 - cell.com
MT1-MMP is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating
pericellular proteolysis of extracellular matrix components. MT1-MMP is therefore thought to …

MT1-MMP expression in the odontogenic region of rat incisors undergoing interrupted eruption

NF Omar, JR Gomes, JS Neves, CR Salmon… - Journal of molecular …, 2011 - Springer
MT1-MMP (membrane type matrix metalloproteinase-1) has been considered an important
membrane-type matrix metalloproteinase involved in the remodeling process in tissue and …

Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development

N Yoshiba, K Yoshiba, C Stoetzel… - … dynamics: an official …, 2003 - Wiley Online Library
The gene expression and protein distribution of matrix metalloproteinase (MMP)2,9,
membrane type1 MMP (MT1MMP), as well as of TIMP1,2, and3 were analyzed during …

Regulation and Interactions of MT1-MMP and MMP-20 in Human Odontoblasts and Pulp Tissue in vitro

H Palosaari, Y Ding, M Larmas, T Sorsa… - Journal of dental …, 2002 - journals.sagepub.com
MT1-MMP is a cell-membrane-bound metalloenzyme that activates other proMMPs such as
proMMP-2 and-13. We studied MT1-MMP expression in mature human odontoblasts and …

Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo

MJ Blanco, I Rodríguez-Martín, AIR Learte… - PLoS …, 2017 - journals.plos.org
Matrix metalloproteinases (MMPs) constitute a large group of endoproteases that play
important functions during embryonic development, tumor metastasis and angiogenesis by …