The matrix metalloproteinase (MMP) family (∼ 25 members in mammals) has been
implicated in extracellular matrix remodeling associated with embryonic development …

Extracellular matrix (ECM) molecules are known to play a pivotal role in morphogenesis of
the secondary palate, and changes in their composition and distribution, not attributable to …

Background Matrix metalloproteinase-20 (Mmp20) ablated mice have enamel that is thin
and soft with an abnormal rod pattern that abrades from the underlying dentin. We asked if …

An intricate balance between extracellular matrix (ECM) synthesis and degradation must be
maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are …

To clarify the involvement of membrane-type matrix metalloproteinase 1 (MT1-MMP) in lung
organogenesis, we studied the lung morphology of 13-day-old MT1-MMP null mice. The …

Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …

Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-
MMP-2 and is essential for skeletal development. We show here that it is required for …

Matrix metalloproteinases (MMPs) play important roles in the turnover of components of
extracellular matrix (ECM) and in the processing of active and latent-signaling molecules …

Background and Objectives: Membrane type 1matrix metalloproteinase (MT1MMP) is a
collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues …

Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell
membranes and activates the zymogen of MMP-2 (gelatinase A). We have recently isolated …