Cholinergic neuromodulation is pivotal for arousal, attention, and cognitive processes. Loss
or dysregulation of cholinergic inputs leads to cognitive impairments like those manifested in …

Substances such as acetylcholine and glutamate act as both neurotransmitters and
neuromodulators. As neuromodulators, they change neural information processing by …

Activation and restoration of cholinergic function remain major foci in the development of
pharmacological approaches toward the treatment of cognitive dysfunctions associated with …

In animal models of Alzheimer's disease (AD), mechanisms of cortical plasticity such as long-
term potentiation (LTP) and long-term depression (LTD) are impaired. In AD patients, LTP …

The neurotransmitter acetylcholine (ACh) regulates many aspects of cognition, including
attention and memory. Previous research in animal models has shown that plasticity in …

Loss of basal forebrain cholinergic innervation of the hippocampus and severe neuronal
loss within the hippocampal CA1 region are early hallmarks of Alzheimer's disease, and are …

Attentional impairments are found in a range of neurodegenerative and neuropsychiatric
disorders. However, the development of procognitive enhancers to alleviate these …

In Alzheimer's disease (AD) patients dysfunction of cholinergic neurons is considered a
typical hallmark, leading to a rationale for the pharmacological treatment in use based on …

The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory
perception, motor control, arousal, attention, learning, and memory. Here we investigate the …

Visuo-attentional deficits occur early in Alzheimer's disease (AD) and are considered more
responsive to pro-cholinergic therapy than characteristic memory disturbances. We …