The hormesis principle of neuroplasticity and neuroprotection
MP Mattson, RK Leak - Cell Metabolism, 2024 - cell.com
Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …
Hormesis: what it is and why it matters
MP Mattson, EJ Calabrese - Hormesis: a revolution in biology, toxicology …, 2010 - Springer
Hormesis describes any process in which a cell, organism, or group of organisms exhibits a
biphasic response to exposure to increasing amounts of a substance or condition (eg …
biphasic response to exposure to increasing amounts of a substance or condition (eg …
[HTML][HTML] How does hormesis impact biology, toxicology, and medicine?
EJ Calabrese, MP Mattson - NPJ aging and mechanisms of disease, 2017 - nature.com
Hormesis refers to adaptive responses of biological systems to moderate environmental or
self-imposed challenges through which the system improves its functionality and/or …
self-imposed challenges through which the system improves its functionality and/or …
[HTML][HTML] A dose of experimental hormesis: When mild stress protects and improves animal performance
R Berry III, G López-Martínez - … and Physiology Part A: Molecular & …, 2020 - Elsevier
The adaptive response characterized by a biphasic curve is known as hormesis. In a
hormesis framework, exposure to low doses leads to protective and beneficial responses …
hormesis framework, exposure to low doses leads to protective and beneficial responses …
Awareness of hormesis will enhance future research in basic and applied neuroscience
MP Mattson - Critical reviews in toxicology, 2008 - Taylor & Francis
Hormesis is defined operationally as responses of cells or organisms to an exogenous or
intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor …
intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor …
Hormesis mediates acquired resilience: Using plant-derived chemicals to enhance health
EJ Calabrese - Annual review of food science and technology, 2021 - annualreviews.org
This review provides an assessment of hormesis, a highly conserved evolutionary dose-
response adaptive strategy that leads to the development of acquired resilience within well …
response adaptive strategy that leads to the development of acquired resilience within well …
[HTML][HTML] Hormesis: path and progression to significance
EJ Calabrese - International journal of molecular sciences, 2018 - mdpi.com
This paper tells the story of how hormesis became recognized as a fundamental concept in
biology, affecting toxicology, microbiology, medicine, public health, agriculture, and all areas …
biology, affecting toxicology, microbiology, medicine, public health, agriculture, and all areas …
Hormesis and disease resistance: activation of cellular stress response pathways
MP Mattson - Human & experimental toxicology, 2008 - journals.sagepub.com
The survival of all organisms depends upon their ability to overcome stressful conditions, an
ability that involves adaptive changes in cells and molecules. Findings from studies of …
ability that involves adaptive changes in cells and molecules. Findings from studies of …
Hormesis: A potential strategic approach to the treatment of neurodegenerative disease
This review describes neuroprotective effects mediated by pre-and post-conditioning-
induced processes that act via the quantitative features of the hormetic dose response …
induced processes that act via the quantitative features of the hormetic dose response …
Building biological shields via hormesis
EJ Calabrese, E Agathokleous - Trends in pharmacological sciences, 2019 - cell.com
Hormesis offers the potential to build biological shields to protect against a plethora of age-
related diseases and acute trauma (eg, brain traumatic injury) via the implementation of pre …
related diseases and acute trauma (eg, brain traumatic injury) via the implementation of pre …