Matrix metalloproteinases (MMPs) degrade most components of the extracellular matrix
(ECM), as well as many nonECM molecules. MMPs participate in (1) degradation of ECM to …

Endochondral ossification, the process by which most of the skeleton is formed, is a powerful
system for studying various aspects of the biological response to degraded extracellular …

Bone-forming cells originate from distinct embryological layers, mesoderm (axial and
appendicular bones) and ectoderm (precursor of neural crest cells, which mainly form facial …

The assembly and degradation of extracellular matrix (ECM) molecules are crucial
processes during bone development. In this study, we show that ECM remodeling is a …

Bone development requires the recruitment of osteoclast precursors from surrounding
mesenchyme, thereby allowing the key events of bone growth such as marrow cavity …

Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

Extracellular matrix (ECM) remodeling is important during bone development and repair.
Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone …

Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …

The metalloproteinase family includes MMP, ADAM and ADAMTS proteases. Mice deficient
in individual or pairs of metalloproteinases have been generated, and a number of these …

The osteocyte is the terminally differentiated state of the osteogenic mesenchymal
progenitor immobilized in the bone matrix. Despite their numerical prominence, little is …