Long bone development depends on endochondral bone formation, a complex process
requiring exquisite balance between hypertrophic cartilage (HC) formation and its …

Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal
pattern of skeletal growth plate vascularization and ossification. Although hypertrophic …

Skeletal tissues develop either by intramembranous ossification, where bone is formed
within a soft connective tissue, or by endochondral ossification. The latter proceeds via …

Like bone mass, bone quality is specified in development, actively maintained postnatally,
and disrupted by disease. The roles of osteoblasts, osteoclasts, and osteocytes in the …

Genetic diseases and knockout mice stress the importance of matrix metalloproteinases
(MMPs) in skeletal turnover. Our study aims at clarifying which MMPs are expressed by …

The matrix metalloproteinase (MMP) family of extracellular proteinases regulates
development and physiologic events. Genetic analyses using transgenic mice that have …

Abstract Background Matrix metalloproteinases (MMPs) not only work as enzymes but also
as degrading enzymes that have been shown to play an important function in extracellular …

We determined the expression pattern of the matrix metalloproteinase interstitial
collagenase (MMP-1) during mouse embryo development using in situ hybridization and …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Matrix metalloproteinases (MMPs) are capable of processing certain components of bone
tissue, including type 1 collagen, a determinant of the biomechanical properties of bone …