Extracellular matrix (ECM) remodeling accompanies cell migration, cell-cell interactions,
embryo expansion, uterine implantation, and tissue invasion during mammalian …

Matrix metalloproteinases (MMPs) are endopeptidases that contribute to growth,
development and wound healing as well as to pathologies such as arthritis and cancer. Until …

It is well established that the expression profiles of multiple and possibly redundant matrix-
remodeling proteases (eg, collagenases) differ strongly in health, disease, and …

The process of regeneration of urodele limbs includes a drastic remodeling of extracellular
matrices (ECMs) that is induced by matrix metalloproteinases (MMPs) and is thought to be …

Osteoclasts require matrix metalloproteinase (MMP) activity and cathepsin K to resorb bone,
but the critical MMP has not been identified. Osteoclasts express MMP-9 and MMP-14 …

Collagenases are involved in cartilage matrix resorption. Using bovine fetal chondrocytes
isolated from physeal cartilages and separated into a distinct prehypertrophic …

Developmental and homeostatic remodeling of the extracellular matrix (ECM) is a highly
regulated process orchestrated by a family of zinc-containing, calcium-dependent neutral …

A decade ago, bone morphogenetic protein 1 (BMP1) was shown to provide the activity
necessary for proteolytic removal of the C-propeptides of procollagens I–III: precursors of the …

The joint is a discrete unit that consists of cartilage, bone, tendon and ligaments. These
tissues are all composed of an extracellular matrix made of collagens, proteoglycans and …

Matrix metalloproteinases (MMPs) are thought to initiate the degradation of the extracellular
matrix during the remodeling of connective tissues. A clear understanding of the …