The best established proteolytic event of osteoclasts is bone matrix solubilization by the
cysteine proteinase cathepsin K. Here, however, we draw the attention on osteoclastic …

Endochondral bone formation is characterized by the progressive replacement of a cartilage
anlagen by bone at the growth plate with a tight balance between the rates of chondrocyte …

Osteoclasts actively remodel both the mineral and proteinaceous components of bone
during normal growth and development as well as pathologic states ranging from …

Tissue-remodeling processes are largely mediated by members of the matrix
metalloproteinase (MMP) family of endopeptidases whose expression is strictly controlled …

Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that
cleave the protein components of the extracellular matrix and thereby play a central role in …

The astacin family (M12A) of the metzincin subclan MA (M) of metalloproteinases has been
detected in developing and mature individuals of species that range from hydra to humans …

Upon termination of bone matrix synthesis, osteoblasts either undergo apoptosis or
differentiate into osteocytes or bone lining cells. In this study, we investigated the role of …

Numerous studies have focused on the expression, regulation, and biological significance of
matrix metalloproteinases (MMPs) in the growth plate. Findings in mouse knockout models …

Bone is regulated by evolutionarily conserved signals that balance continuous differentiation
of bone matrix-producing cells against apoptosis and matrix removal. This is continued from …

Peri-cellular remodeling of mesenchymal extracellular matrices is considered a prerequisite
for cell proliferation, motility and development. Here we demonstrate that membrane-type 3 …