Synchrotron-based x-ray fluorescence microscopy, immunofluorescence, and Western
blotting were used to investigate changes in copper (Cu) and Cu-associated pathways in the …

Copper is a biometal essential for normal brain development and function, thus copper
deficiency or excess results in central nervous system disease. Well-characterized disorders …

Copper is a transition metal that has been linked to pathological and beneficial effects in
neurodegenerative diseases. In Parkinson's disease, free copper is related to increased …

The involvement of copper in numerous physiological processes makes this metal ion
essential for human life. Alterations in copper homeostasis might have deleterious …

Elevated iron and decreased copper levels are cardinal features of the degenerating
substantia nigra pars compacta in the Parkinson's disease brain. Both of these redox-active …

Several studies of Parkinson's disease (PD) have reported dysregulation of cerebral metals,
particularly decreases in copper and increases in iron in substantia nigra (SN). However …

As a cofactor of proteins and enzymes involved in critical molecular pathways in mammals
and low eukaryotes, copper is a transition metal essential for life. The intra-cellular and extra …

Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial
and sporadic Parkinson's disease (PD). An increase in copper (Cu) levels has been …

Copper is an essential trace metal which plays a fundamental role in the biochemistry of the
human nervous system. Menkes disease and Wilson disease are inherited disorders of …

Copper is an essential element for the activity of a number of physiologically important
enzymes. Enzyme-related malfunctions may contribute to severe neurological symptoms …