The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

Different effects of normal aging on muscarinic and nicotinic receptor subtypes were
observed in postmortem brain tissue from different regions of the human brain. A significant …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have
been examined in the hippocampus obtained at autopsy from a variety of patients with …

The total population of muscarinic receptors and a subpopulation of muscarinic receptors
with high affinity for agonists were measured with [3 H] quinuclidinyl benzilate and [3 H] …

Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

Cholinergic nicotinic and muscarinic receptor binding were measured in post mortem
human brain tissue, using low (nM) concentrations of (3 H)-nicotine to detect predominately …

The status of cholinergic receptors in dementia is related to the question of potential
cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or …

Brain nicotinic receptors were studied in the frontal cortex, temporal cortex, hippocampus
and caudate nucleus in patients with Parkinson's disease (PD), Alzheimer's disease (AD) …