We have recently reported on the differential alterations of various cholinergic markers in
cortical and subcortical regions in Alzheimer's disease (AD). The main purpose of the …

The brain systems mostly affected by Alzheimer's disease (AD) are listed in Table 1 (Rossor
et al., 1982; Bird et al., 1983; Davies, 1979). They include either neuronal populations which …

Muscarinic and nicotinic binding sites were analysed in lymphocytes from patients with
Alzheimer's disease, Multi-infarct dementia, Parkinson's disease and age-matched controls …

Neurochemical studies on human brains obtained at autopsy have over the past two
decades contributed much to our understanding of the role of distinct neurotransmitter …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

The literature concerning age effects on cholinergic neurochemical parameters, in the brain
presents a heterogeneous picture, both within and among species. Whereas some studies …

Cholinergic muscarinic receptors in aged and young rat brains were studied by quantitative
autoradiography of tritiated quinuclidinyl benzilate. A selective pattern of decreased binding …

Molecular subtypes of muscarinic receptors (m1–m5) are novel targets for cholinergic
replacement therapies in Alzheimer's disease. However, the status of these receptors in …

Brain muscarinic M1 and M2 binding sites, as defined by their affinity for pirenzepine, were
studied in 24 regions of 3 normal control brains. For each region, the binding of [3 H] QNB, a …