In vivo probing of the brain cholinergic system in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.

A Imperato, MG Scrocco, O Ghirardi… - Annals of the New …, 1991 - europepmc.org
The regulation of acetylcholine (ACh) release by the different subtypes of muscarinic (M)
receptors in the hippocampus of freely-moving Fischer and Sprague-Dawley rats, was …

Nicotinic acetylcholine receptors in Alzheimer's disease

A Wevers, H Schröder - Journal of Alzheimer's Disease, 1999 - content.iospress.com
Nicotinic cholinoceptive dysfunction associated with cognitive impairment is a leading
neurochemical feature of Alzheimer's disease. There-fore, nicotinic acetylcholine receptors …

High-affinity choline uptake and muscarinic receptors in rat brain during aging

Z Krištofiková, J Klaschka, H Tejkalová… - Archives of gerontology …, 1992 - Elsevier
The aim of this study was to determine the effect of aging on the high-affinity choline uptake
(HACU) and the muscarinic acetylcholine receptors (mAChR) in the brain of Wistar male rats …

Conformational changes in muscarinic receptors may produce diminished cholinergic neurotransmission and memory deficits in aged rats

AS Lippa, CC Loullis, J Rotrosen, DM Cordasco… - Neurobiology of …, 1985 - Elsevier
Both clinical and laboratory studies suggest that age-related memory deficits may be due, at
least in part, to disturbances in muscarinic acetylcholine (mAChR) receptors. In order to …

Autoradiographic localization of muscarinic cholinergic receptors in the hippocampus of patients with senile dementia

JM Palacios - Brain Research, 1982 - Elsevier
Muscarinic cholinergic receptors were localized by autoradiography in the hippocampi from
4 patients with senile dementia (SD) and 4 neurologically normal age-matched controls. A …

Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's dementia

ED London, MJ Ball, SB Waller - Neurochemical research, 1989 - Springer
Postmortem cerebral neocortical and hippocampal samples were taken from patients who
died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of …

Cortical nicotinic receptors in Alzheimer's disease and Parkinson's disease.

KW Lange, FR Wells, MN Rossor, P Jenner… - Journal of neurology …, 1991 - ncbi.nlm.nih.gov
The exact cellular location of nicotinic cholinergic receptors in the cerebral cortex is not
known. The parallel changes in these receptors and CAT activity in AD and PD suggest that …

Cholinergic deficits in aged rat brain are corrected with nicergoline

N Ogawa, M Asanuma, H Hirata, Y Kondo… - Archives of gerontology …, 1993 - Elsevier
Choline acetyltransferase (CAT) and muscarinic cholinergic receptor (MCR) activities are
markedly reduced in aged as compared with young-adult rat brain. Nicergoline was found to …

In Vivo Quantification of Cerebral Muscarinic Receptors in Normal Human Aging Using Positron Emission Tomography and [11C]Tropanyl Benzilate

KS Lee, KA Frey, RA Koeppe, A Buck… - Journal of Cerebral …, 1996 - journals.sagepub.com
Regional cerebral muscarinic cholinergic receptor binding was quantified in normal young
and elderly subjects employing the muscarinic antagonist radioligand [11C] tropanyl …

Choline acetyltransferase activity and muscarinic binding in brain regions of aging Fischer-344 rats

SB Waller, ED London - Neurochemistry international, 1989 - Elsevier
Muscarinic receptor binding and choline acetyltransferase (EC 2.3. 1.6.) activity were
assayed in three brain regions of 4-, 12-and 24-month-old Fischer-344 rats. Statistically …