A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

The cholinergic system, particularly the cortically projecting neurons situated in the basal
forebrain, is clearly involved in a variety of human disorders associated with dementia …

Multiple nicotinic receptors seem to exist in brain as revealed by neurophysiological,
neurochemical, molecular and immunological studies. The mechanisms for their …

The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

Publisher Summary This chapter discusses the role of nicotinic receptors in the
pathophysiology of Alzheimer's disease (AD). The nicotinic receptor binding sites in human …

A general review of cholinergic receptors in human brain is presented. The paper focuses
upon changes in normal aging brain and in Alzheimer disease. Studies from five different …

Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex
(area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged …

Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four
histologically normal controls and five histopathologically verified cases of Alzheimertype …