Nicotinic cholinergic receptors in human brain: effects of aging and Alzheimer

E Giacobini - Plasticity and Regeneration of the Nervous System, 1991 - Springer
A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

Cholinergic neuropathology and nicotinic receptor binding in the human brain

EK Perry, CJ Smith, JH Xuereb, AB Keith… - … acetylcholine receptors in …, 1988 - Springer
The cholinergic system, particularly the cortically projecting neurons situated in the basal
forebrain, is clearly involved in a variety of human disorders associated with dementia …

Human nicotinic receptors—their role in aging and dementia

A Nordberg - Neurochemistry international, 1994 - Elsevier
Multiple nicotinic receptors seem to exist in brain as revealed by neurophysiological,
neurochemical, molecular and immunological studies. The mechanisms for their …

Brain nicotinic and muscarinic receptors in normal aging and dementia

A Nordberg, B Winblad - … and Parkinson's Disease: Strategies for Research …, 1986 - Springer
The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

The role of nicotinic receptors in the pathophysiology ofAlzheimer's disease

A Nordberg, L Nilsson-Håkansson, A Adem… - Progress in brain …, 1989 - Elsevier
Publisher Summary This chapter discusses the role of nicotinic receptors in the
pathophysiology of Alzheimer's disease (AD). The nicotinic receptor binding sites in human …

Cholinergic receptors in human brain: effects of aging and Alzheimer disease

E Giacobini - Journal of neuroscience research, 1990 - Wiley Online Library
A general review of cholinergic receptors in human brain is presented. The paper focuses
upon changes in normal aging brain and in Alzheimer disease. Studies from five different …

Cellular distribution and expression of cortical acetylcholine receptors in aging and Alzheimer's disease.

H Schröder, E Giacobini, RG Struble… - Annals of the New …, 1991 - europepmc.org
Ligand binding studies show marked reductions of nicotinic, but not of muscarinic binding
sites in Alzheimer's disease. Using monoclonal antibodies we studied …

Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

E Giacobini, RG Struble, K Zilles, A Maelicke - Neurobiology of aging, 1991 - Elsevier
The cellular distribution of nicotinic acetylcholine receptors was studied in the frontal cortex
(area 10) of 1) Alzheimer patients and compared to 2) age-matched and 3) middle-aged …

The cholinergic receptor system of the human brain: neurochemical and pharmacological aspects in aging and Alzheimer

E Giacobini, P DeSarno, B Clark, M McIlhany - Progress in brain research, 1989 - Elsevier
Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

Changes in nicotinic and muscarinic cholinergic receptors in Alzheimertype dementia

S Shimohama, T Taniguchi, M Fujiwara… - Journal of …, 1986 - Wiley Online Library
Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four
histologically normal controls and five histopathologically verified cases of Alzheimertype …