Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells
K Cotter, J Capecci, S Sennoune, M Huss… - Journal of Biological …, 2015 - ASBMB
The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps that
couple ATP hydrolysis with translocation of protons across membranes. Previous studies …
couple ATP hydrolysis with translocation of protons across membranes. Previous studies …
The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells
J Capecci, M Forgac - Journal of Biological Chemistry, 2013 - ASBMB
The vacuolar H+ ATPases (V-ATPases) are ATP-driven proton pumps that transport protons
across both intracellular and plasma membranes. Previous studies have implicated V …
across both intracellular and plasma membranes. Previous studies have implicated V …
[HTML][HTML] The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast …
K Cotter, R Liberman, GH Sun-Wada, Y Wada… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps
that acidify intracellular compartments and transport protons across the plasma membrane …
that acidify intracellular compartments and transport protons across the plasma membrane …
Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells
CM McGuire, MP Collins, GH Sun-Wada… - Journal of Biological …, 2019 - ASBMB
The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump present in various
intracellular membranes and at the plasma membrane of specialized cell types. Previous …
intracellular membranes and at the plasma membrane of specialized cell types. Previous …
Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells
A Hinton, SR Sennoune, S Bond, M Fang… - Journal of Biological …, 2009 - ASBMB
It has previously been shown that highly invasive MDA-MB231 human breast cancer cells
express vacuolar proton-translocating ATPase (V-ATPases) at the cell surface, whereas the …
express vacuolar proton-translocating ATPase (V-ATPases) at the cell surface, whereas the …
[HTML][HTML] Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness
C McGuire, K Cotter, L Stransky, M Forgac - Biochimica et Biophysica Acta …, 2016 - Elsevier
V-ATPases are ATP-driven proton pumps that function within both intracellular
compartments and the plasma membrane in a wide array of normal physiological and …
compartments and the plasma membrane in a wide array of normal physiological and …
Vacuolar-type proton pump ATPases: acidification and pathological relationships.
GH Sun-Wada, Y Wada - Histology and histopathology, 2013 - europepmc.org
Vacuolar H (+)(-) translocating ATPase (V-ATPase) is a universal proton pump, and its
activity is required for a variety of cell biological processes, such as membrane trafficking …
activity is required for a variety of cell biological processes, such as membrane trafficking …
Extracellular and luminal pH regulation by vacuolar H+-ATPase isoform expression and targeting to the plasma membrane and endosomes
GA Smith, GJ Howell, C Phillips, SP Muench… - Journal of Biological …, 2016 - ASBMB
Plasma membrane vacuolar H+-ATPase (V-ATPase) activity of tumor cells is a major factor
in control of cytoplasmic and extracellular pH and metastatic potential, but the isoforms …
in control of cytoplasmic and extracellular pH and metastatic potential, but the isoforms …
Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity
SR Sennoune, K Bakunts… - … of physiology-cell …, 2004 - journals.physiology.org
Tumor cells thrive in a hypoxic microenvironment with an acidic extracellular pH. To survive
in this harsh environment, tumor cells must exhibit a dynamic cytosolic pH regulatory system …
in this harsh environment, tumor cells must exhibit a dynamic cytosolic pH regulatory system …
Regulation of V-ATPase assembly in nutrient sensing and function of V-ATPases in breast cancer metastasis
MP Collins, M Forgac - Frontiers in Physiology, 2018 - frontiersin.org
V-ATPases are proton pumps that function to acidify intracellular compartments in all
eukaryotic cells, and to transport protons across the plasma membrane of certain …
eukaryotic cells, and to transport protons across the plasma membrane of certain …