Background In animal studies early life antibiotic exposure causes metabolic abnormalities
including obesity through microbiota disruption, but evidence from human studies is scarce …

Purpose Antibiotic use is associated with alteration of the gut microbiome and metabolic
activity. As childhood obesity is a predisposing factor for adult obesity, addressing childhood …

Background: Obesity has been associated with disruption of the gut microbiota, which is
established during infancy and vulnerable to disruption by antibiotics. Objectives: To …

Background Prenatal antibiotic exposure has been associated with an altered infant gut
microbiome composition and higher risk of childhood obesity, but no studies have examined …

Background Early-life antibiotic exposure is associated with the development of later obesity
through the disruption of gut microbiota in the animal models. However, the related …

Antibiotics are often prescribed inappropriately to infants and young children, with potentially
adverse effects on the developing gut microbiota and related metabolic processes. We …

Objective: To investigate whether antibiotic exposure during the first year of life is associated
with increased childhood body mass index (BMI). Design: Secondary analysis from a multi …

We conducted a systematic review and metaanalysis of observational studies investigating
the association between antibiotic exposure in infancy and risk of childhood overweight and …

Background Childhood obesity and overweight are among the greatest health challenges in
the pediatric population. Obese individuals exhibit marked differences in the composition of …

Importance Early-life antibiotic exposure has been associated with increased adiposity in
animal models, mediated through the gut microbiome. Infant antibiotic exposure is common …