The ability of exercise to decrease fat mass and increase bone mass may occur through
mechanical biasing of mesenchymal stem cells (MSCs) away from adipogenesis and toward …

Mechanical stimulation can prevent adipogenic and improve osteogenic lineage allocation
of mesenchymal stem cells (MSC), an effect associated with the preservation of β-catenin …

Regulation of skeletal remodeling appears to influence the differentiation of multipotent
mesenchymal stem cells (MSC) resident in the bone marrow. As murine marrow cultures are …

A reciprocal relationships between osteogenesis and adipogenesis has been observed in
vitro and in vivo, and mechanical stretch has been believed to be a regulating factor of osteo …

Osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) are
regarded as being of great importance in the regulation of bone remodeling. In this study, rat …

Because a lack of mechanical information favors the development of adipocytes at the
expense of osteoblasts, we hypothesized that the peroxisome proliferator-activated receptor …

This study examined the effects of mechanical strain on osteogenic and adipogenic
differentiation of cultured MSCs by stimulating MSCs cultured in general and adipogenic …

Mechanical signals can inactivate glycogen synthase kinase 3β (GSK3β), resulting in
stabilization of β-catenin. This signaling cascade is necessary for the inhibition of …

Mesenchymal stem cells (MSCs) are defined by their ability to selfrenew and differentiate
into the cells that form mesodermal tissues such as bone and fat. Low magnitude …

The fate of pluripotent mesenchymal stem cells (MSC) is determined through integration of
chemical, spatial, and physical signals. The suppression of MSC adipogenesis by …