The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

Great emphasis is being placed on identification of neurotransmitter systems involved in the
symptomatic manifestations of neurological and psychiatric disorders. In the case of …

The cholinergic hypothesis of Alzheimer's disease (AD) states 1. that cholinergic neurons in
the basal forebrain are severely affected in the course of disease, detectable both …

Normal aging and Alzheimer's disease are characterized by similar morphological, chemical
and behavioral changes. These include cell loss, senile plaque formation, the presence of …

Neurochemical studies on human brains obtained at autopsy have over the past two
decades contributed much to our understanding of the role of distinct neurotransmitter …

The so-called “cholinergic hypothesis” assumes that degenerative dysfunction of the
cholinergic system originating in the basal forebrain and innervating several cortical regions …

Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities have been
examined postmortem in a series of 66 individuals with no evidence of CNS disease …

In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the
cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study,[3 …

The main objective of the present study was to determine whether cholinergic markers
(choline acetyltransferase activity and nicotinic and muscarinic receptors) are altered in …