Background Variation in CACNA1C has consistently been associated with psychiatric
disease in genome-wide association studies. We have previously shown that healthy …

Variation in the CACNA1C gene has consistently been associated with psychosis in
genome wide association studies. We have previously shown in a sample of n= 110 healthy …

Background Neuropsychiatric disorders are highly heritable and have overlapping genetic
underpinnings. Single nucleotide polymorphisms (SNPs) in the gene CACNA1C have been …

Background: Genomewide association studies have identified the rs1006737 single
nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for …

Genome-wide association studies have suggested that allelic variations in the CACNA1C
gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we …

Context TheCACNA1Cgene (α-1C subunit of the L-type voltage-gated calcium channel) has
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …

Context The neural abnormalities underlying genetic risk for bipolar disorder, a severe,
common, and highly heritable psychiatric condition, are largely unknown. An opportunity to …

Sex is a powerful modulator of disease susceptibility, course and outcome. The gene
CACNA1C is among the best replicated vulnerability genes of bipolar disorder and …

Recent genetic association studies have identified the A-allele of rs1006737 within
CACNA1C as a risk factor for schizophrenia as well as mood disorders. Some evidence …

CACNA1C gene polymorphism rs2007044 has been reported to be associated with
schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an …