This study aimed to conduct a quantitative meta-analysis for the values of, and variability in,
gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the …

This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

One purpose of this study was to develop a new system for the prediction of pHdependent
soluble drug absorption that takes into account the physiological condition of the …

Water volume has impact when the compound has low aqueous solubility. For example, the
absorption of compounds with a Biopharmaceutics Classification System class 2 or 4 is …

The aim of the present study was to evaluate the effects of gastric pH on the oral absorption
of poorly water-soluble drugs using an in vitro system. A dissolution/permeation system (D/P …

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …

The aim of the current research was to develop an in silico oral absorption model coupled
with an in vitro dissolution/precipitation testing to predict gastric pH-dependent drug-drug …

The bioavailability of an orally administered small molecule is often dictated by drug-specific
physicochemical characteristics and is influenced by many biological processes. For …

Published reports have clearly shown that weakly basic drugs which have low solubility at
high pH could have impaired absorption in patients with high gastric pH thus leading to …

Drug-drug, drug-formulation and drug-meal interactions are of clinical concern for orally
administered drugs that possess a narrow therapeutic index. This review presents the …